PurposeAccurate segmentation of tumor-infected regions in retinal Optical Coherence Tomography (OCT) images is critical for early diagnosis and clinical decision-making. However, conventional deep learning and transformer-based models often struggle to delineate overlapping and inter-dependent pixel features, leading to reduced segmentation precision. This study proposes a novel Dependent Inter-Feature Segmentation Method (DIFSM) to improve the localization and segmentation of retinal tumor regions in OCT images.MethodsThe proposed DIFSM framework integrates advanced image preprocessing, inter-feature dependency analysis, and a Vision Transformer (ViT) architecture to distinguish differentiable and non-differentiable features. Overlapping pixel regions are identified through inter-feature intensity and gradient analysis, which are indicative of tumor-affected areas. The Vision Transformer is trained using matched and unmatched inter-feature representations to enhance contextual learning and resolve feature ambiguities. Experiments were conducted on the OCTID dataset comprising high-resolution retinal OCT images, and performance was evaluated using Dice coefficient, Intersection over Union (IoU), precision, sensitivity, specificity, and Mean Square Matching Error (MSME). Comparative analysis was performed against state-of-the-art segmentation models.ResultsThe proposed DIFSM model achieved a Dice coefficient of 96.2% and an IoU of 94.8%, demonstrating excellent spatial overlap with expert-validated tumor regions. Precision, sensitivity, and specificity reached 96.8%, 96.6%, and 96.7%, respectively, while MSME was reduced to 6.11%. Compared to existing methods, DIFSM improved segmentation accuracy by 14.39%, precision by 14.11%, and reduced MSME by 13.5%. The model consistently outperformed benchmark approaches in detecting macular hole and central serous retinopathy-associated tumor regions while maintaining robustness to noise and structural variability.ConclusionThe proposed DIFSM framework effectively addresses the limitations of existing OCT segmentation methods by explicitly modeling inter-feature dependencies and resolving overlapping pixel ambiguities using a Vision Transformer. The significant improvements in segmentation accuracy and error reduction highlight its potential as a reliable and clinically applicable tool for automated retinal tumor detection in ophthalmic imaging. DIFSM offers a promising direction for enhancing OCT-based diagnostic systems and supporting ophthalmologists in early disease identification and treatment planning.