The present work deals with the GC MS analysis of one Ayurvedic medicine, Sukumaram Kashayam, mainly prescribed for gynaecological ailments. The medicine was procured from standard Ayurvedic medicine vendor at Chennai, and was processed as per protocol before subjecting it to GC MS analysis. Some important biomolecules such as, Benzoic acid, 2, 4, 6-Cycloheptatrien-1-one, 2-hydroxy-, Cyclobutane-1,1-dicarboxamide, N, N'-di-benzoyloxy-, Z-10-Methyl-11-tetradecen-1-ol propionate, 5, 8, 11, 14-Eicosatetraynoic acid, methyl ester etc. were observed which have direct or indirect roles in curing the uterus related problems. It is concluded that the GC MS indicated some important biomolecules that could support that could support the role of SukumaramKashayam as formulation for Gynaecological ailments.