Green synthesized nanoparticles of ZNO with leaves of Epipremnum aureum has been tested against PA-1 cell line (Ovarian Cancer) and the IC50 value was found. The nanoparticles were prepared from leaves of Epipremnum aureum, commonly called money plant, by standard procedures. The anticancer study was conducted by MTT assay and the cytotoxic effect was compared with standard Cisplatin. It was observed thatthe IC50 values for Cisplatin treatment was 2.728 whereas that of ZnO nanoparticles of E. aureum was 16.487. Thus it is clear that E. aureum does have good cytotoxic effects on PA-1 cancer cell lines. It could give even better results if the concentrations of treatment in increased towards which studies are on.