Background:Sialadenosis or sialosis is the asymptomatic symmetric parotid enlargement without inflammation or neoplasia, seen in persons 30-69 years old, often related to chronic alcohol use, endocrine disorders, and obesity.Materials and Methods:This was a case-control study done at Rajah Muthiah Dental College and Hospital from September 2013 to July 2014, comprising 15 patients with alcoholic sialadenosis (Group A) and comparing them with 15 alcoholic patients without sialadenosis (Group B). Parameters monitored for liver and pancreatic functions were their serum levels of AST, ALT, GGT, ALP, amylase, and lipase.Results:Group A had higher mean levels of GGT, AST, and ALT; a slightly increased AST/ALT ratio; and high serum amylase and lipase compared to Group B. Both groups consumed ethanol in excess.Conclusion:Biochemical differences suggest chronic alcohol effects on sialadenosis. Stable hepatic and pancreatic functions indicate that further research into sialadenosis may provide a potential diagnostic marker for liver and pancreatic disorders.