Introduction: Many ancient medical systems, including Ayurveda and Unani, have utilised plants as therapeutic agents for ages. Both structured and unstructured types of medicinal plants have been used extensively to treat a variety of illnesses, including cognitive impairment. One plant identified as having the ability to cure neurological conditions and enhance cognitive function is Evolvulus alsinoides Linn, also referred to as Vishnukranthi. Aim: To evaluate the effect of Evolvulus alsinoides methanolic extract in treating sodium nitrite-induced amnesia in male Swiss albino mice through behavioural, biochemical and histological parameters. Materials and Methods: This experimental study was conducted at ACS Medical College and Hospital, Dr. MGR Educational and Research Institute, Velappanchavadi, Chennai, Tamil Nadu, India. Healthy male Swiss albino mice weighing between 25 and 30 g were used as subjects. The experiment was designed to evaluate the potential cognitive-enhancing effects of Evolvulus alsinoides through two behavioral tests: the Elevated Plus Maze (EPM) test and the passive avoidance test. The EPM test is commonly employed to assess anxiety and memory by measuring the time animals spend in the open arms versus the closed arms of the maze. It also evaluates the total transitions made by the animals between the arms, providing insights into their exploratory and memory behaviour. Results: A notable difference wasobserved between the sodium nitrite-treated group (GSN) and the sodium nitrite-treated with piracetam group (GSNP), where the piracetam-treated mice (GSNP) exhibited a significant reduction (p-value=0.0001) in the number of transitions. The Evolvulus alsinoides-treated groups (GSNLD and GSNHD) showed a significant reduction in the number of transitions when compared to the GSN group. In the passive avoidance test, the comparison between GSN and groups GSNLD and GSNHD (treated with Evolvulus alsinoides) showed a statistically significant improvement in step-down latency in the treated groups. Biochemical parameters of brains indicated reduced GSH and AChE levels, which were considered supportive evidence for the behavioural parameters. Conclusion: These findings suggest that Evolvulus alsinoides may be a promising agent for the development of new treatments for memory impairment and cognitive disorders.