Background:Fluorides are the most important pollutants present in the effluents from various industrial and groundwater sources. These are very poisonous to living beings and have a dangerous effect on their health. Fluoride in drinking water within permissible limits of 0.5-1.0 mg/L is useful for the production and of maintenance healthy, teeth and bones as extreme intake of fluoride causes dental and skeletal fluorosis. Thus the removal of fluoride using adsorbents is a main step towards the protection of environment.Methods:The water samples are collected from wells of Salem district. Previous to sampling, the water is left to run from the source for few minutes. The study for presence of fluoride in groundwater samples is carried out as per APHA standard methods. Fluoride concentration be determined with SPADNS method spectrometric ally by use zirconyl-SPADNS (sodium 2-(parasulphophenylazo)-1, 8-dihydroxy-3, 6-naphthalene-disulphonate) reagents.Results:The significant difference in average score is tested through the analysis of variance after testing the normality test and it shows there is highly significant difference is found in the Fluoride Removal with respect to Moringaoleifera seeds, Moringaoleifera leaves, Moringaoleifera barks since the p value is less than 0.01.Conclusion:Drinking water is an essential basic need. The use of adsorbents is simple, cheap, non-toxic and environmentally friendly, its adoption for the defluoridation of drinking water. Based on the results of this study, it can be concluded that the low-cost adsorbents are effective in removal of fluoride from water.