Background:Chronic kidney disease (CKD) is a chronic condition characterized by irreversible renal dysfunction, leading to excretory and metabolic failure. Patients with end-stage renal disease (ESRD) often have elevated CRP and reduced albumin levels, causing inflammation. This study compares serum CRP, albumin, urea, creatinine, eGFR, blood pressure, and weight in patients on MHD with ESRD.Methodology:The study measured weight, eGFR, systolic and diastolic blood pressure, serum CRP, albumin, urea, and creatinine in 90 MHD patients and 90 controls using various methods, including GLDH, Jaffe's, BCG, and Nephelometry.Results:The CRP levels in pre hemodialysis were 4.74 +/- 2.25 mg/dl and the control group had 0.6 +/- 0.2 mg/dl. So comparison of both CRP and albumin in cases and control were highly significant. The pre hemodialysis albumin was 2.74 +/- 0.7 mg/dl and control were measured as 4.2 +/- 0.5 mg/dl which is statistically significant. The Urea levels in pre hemodialysis were 112.2 +/- 23.7 mg/dl and the control group had 24.9 +/- 6.2 mg/dl. The Creatinine levels in pre hemodialysis were 8.5 +/- 2.7 mg/dl and the control group had 0.8 +/- 0.1 mg/dl. The Systolic Blood Pressure (SBP) in pre hemodialysis were 167.0 +/- 21.4 mm of Hg and the control group had 121.9 +/- 6.9 mm of Hg. The Diastolic Blood Pressure (DBP) in pre hemodialysis were 88.8 +/- 10.7 mm of Hg and the control group had 76.8 +/- 4.6 mm of Hg. The eGFR in pre hemodialysis was 7.3 +/- 4.1 mL/min/1.73 m2 and the control group had 98.7 +/- 17.7 mL/min/1.73 m.Conclusion:The study found that patients with MHD had significantly higher CRP, albumin, Urea, Creatinine, SBP, and DBP levels compared to controls, with decreased albumin levels and increased CRP in ESRD patients.