Post-COVID-19 Complications: A Study on Long COVID Symptoms and Their Pathophysiology

Sekar, Priyanka and Dominic, Melvin and Balakrishnan, Sudhiersharan and Sreelakshmi, V. K. and Haneendhar, R. and Gopan, S. Jithin and Rathnasami, Pragnesh and Moturi, Sai Vineeth (2025) Post-COVID-19 Complications: A Study on Long COVID Symptoms and Their Pathophysiology. JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 17.0 (SUPPL ). S2557-S2559. ISSN 0976-4879

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Abstract

Background:Long COVID refers to persistent symptoms lasting weeks or months after recovery from acute COVID-19. These symptoms can affect multiple systems and impair quality of life.Objective:To assess the prevalence, pattern, and probable pathophysiological mechanisms of long COVID symptoms in recovered patients.Materials and Methods:A cross-sectional study was conducted over 12 months among 210 adults recovered from COVID-19 (>= 12 weeks postinfection). Clinical evaluation, lab investigations, and imaging were used to identify post-COVID symptoms and explore underlying mechanisms.Results:Common symptoms included fatigue (67.6%), breathlessness (42.8%), cognitive issues (39.5%), and myalgia (34.7%). Neuropsychiatric complaints were noted in 41%, while 29% had cardiopulmonary sequelae. Elevated inflammatory markers correlated with symptom persistence (P < 0.05).Conclusion:Long COVID involves diverse symptoms, primarily fatigue and neurorespiratory complaints. Immune dysregulation and systemic inflammation appear central to its pathophysiology.

Item Type: Article
Uncontrolled Keywords: Breathlessness, fatigue, inflammation, long COVID, post-viral syndrome
Subjects: Pharmacology, Toxicology and Pharmaceutics > Pharmacology & Pharmacy
Divisions: Medicine > Vinayaka Mission's Kirupananda Variyar Medical College and Hospital, Salem > Emergency Medicine
Medicine > Vinayaka Mission's Kirupananda Variyar Medical College and Hospital, Salem > General Medicine
Depositing User: Unnamed user with email techsupport@mosys.org
Last Modified: 06 Feb 2026 07:11
URI: https://ir.vmrfdu.edu.in/id/eprint/6817

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