Preemptive analgesia with tapentadol in inguinal surgery; a randomized controlled trial

Vadhanan, Prasanna and Rajendran, Iniya and Kumar, Vinith (2023) Preemptive analgesia with tapentadol in inguinal surgery; a randomized controlled trial. ANAESTHESIA PAIN & INTENSIVE CARE, 27.0 (3). pp. 356-359. ISSN 1607-8322

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Abstract

Background & Objective: Preemptive analgesia aims at minimizing the development of central sensitization thereby decreasing postoperative pain and analgesic requirements. Various drugs have been used for this purpose. Tapentadol, is a newer centrally acting analgesic which is effective in moderate to severe pain. The aim of this study was to analyze the effect of preoperative oral tapentadol upon postoperative analgesia and analgesic requirements in patients undergoing inguinal hernia surgeries.Methodology: One hundred adult patients undergoing elective unilateral inguinal hernia repair were randomized into two groups of fifty each. Group P received placebo tablets and Group T received tapentadol (100 mg) tablets orally 30 min before anesthesia. All patients received spinal anesthesia and the duration of postoperative analgesia and analgesic consumption in the first postoperative day was recorded. Diclofenac was administered when the patients demanded analgesia.Results: Time for first analgesic demand was significantly delayed in Group T as compared to Group P (328.00 & PLUSMN; 129.71 vs. 252.00 & PLUSMN; 101.38 min, P = 0.017) and the total analgesic consumption of diclofenac was also less than in the placebo group (73.33 & PLUSMN; 28.57 mg vs. 95.00 & PLUSMN; 31.30 mg; P = 0.006). No adverse events were observed in either group.Conclusion: Preemptive oral tapentadol is effective for minimizing postoperative pain and analgesic requirement in patients undergoing inguinal hernia surgeries under spinal anesthesia.

Item Type: Article
Uncontrolled Keywords: Anesthesia, Spinal, Tapentadol, Hernia surgery, Analgesia, Postoperative
Subjects: Medicine > Anesthesiology
Divisions: Nursing > Vinayaka Mission's Annapoorna College of Nursing, Salem
Medicine > Vinayaka Mission's Medical College and Hospital, Karaikal
Nursing > Vinayaka Mission's College of Nursing, Karaikal
Nursing > Vinayaka Mission's College of Nursing, Puducherry
Pharmacy > Vinayaka Mission’s College of Pharmacy, Salem
Physiotherapy > Vinayaka Mission's College of Physiotherapy, Salem
Homoeopathy > Vinayaka Mission's Homoeopathic Medical College and Hospital, Salem
Medicine > Vinayaka Mission's Kirupananda Variyar Medical College and Hospital, Salem
Arts and Science > Vinayaka Mission's Kirupananda Variyar Arts and Science College, Salem, India
Engineering and Technology > Vinayaka Mission's Kirupananda Variyar Engineering College, Salem, India
Law > Vinayaka Mission's Law School, Chennai
Medicine > Vinayaka Mission's Medical College, Kottucherry
Medicine > Vinayaka Mission's Medical College, Puducherry
Physical Education > Vinayaka Mission's College of Physical Education, Salem
Interdisciplinary Studies > Vinayaka Mission's School of Health Systems, Chennai
Dentistry > Vinayaka Mission‘s Sankarachariyar Dental College, Salem
Liberal Arts > Vinayaka Mission's School of Economics and Public Policy, Chennai
Depositing User: Unnamed user with email techsupport@mosys.org
Last Modified: 06 Feb 2026 07:10
URI: https://ir.vmrfdu.edu.in/id/eprint/6800

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