Background: Nursing profession execute an imperative role in health promotion, disease, and injury prevention, providing care and assist in cure of patients with diverse age groups, and backgrounds both in individual and community settings. The study aimed to determine and compare the oral health knowledge, attitude, and practice (KAP) with oral health status among nursing students in Salem. Materials and Methods: A cross-sectional study was conducted on nursing students of Vinayaka Mission's Annapoorna College of Nursing, Salem, Tamil Nadu, India. The study included self-administered questionnaire covering demographic details and oral health KAP questions (18-items) followed by oral examination using the World Health Organization survey (2013). Data analysis was performed using SPSS 22. Results: Two hundred and sixty-one students were included in the survey (63 males and 198 females). Females reported better mean +/- standard deviation (SD) in knowledge (24.08 +/- 4.3), attitude (5.43 +/- 1.3), and practice (10.82 +/- 1.5, P = 0.000) than males. Moreover third-year students had higher mean +/- SD scores in knowledge (24.42 +/- 4.3) and practice (10.89 +/- 1.7) while higher mean +/- SD attitude scores (5.61 +/- 1.2) was reported among second years. Relationship between attitude-practice indicated a positive significant correlation (r = 0.145, P = 0.05). Conclusions: There are an adequate knowledge, negative attitude, and inadequate practice toward oral health among nursing students. The study introspects the gap between knowledge and actions. As attitude influence on a person's behavior, discriminate knowledge in the right direction to best bring out the outcomes.