This study investigated operational and structural health monitoring (SHM) as well as damage evaluations for building structures. The study involved damage detection and the assessment of buildings by placing sensors and by assuming weak areas, and considered situations of assessment and self-monitoring. From this perspective, advanced sensor technology and data acquisition techniques can systematically monitor a building in real time. Furthermore, the structure's response and behavior were observed and recorded to predict the damage to the building. In this paper, we discuss the real-time monitoring and response of buildings, which includes both static and dynamic analyses along with numerical simulation studies such as finite element analysis (FEA), and recommendations for the future research and development of SHM are made.