Aim/Background: This research explores the pharmaceutical industry's operations management, focusing on regulatory-based operation management for parenteral preparations. Materials and Methods: The study utilizes a comprehensive review of literature and industry practices to examine the application of operations management in the pharmaceutical sector. It incorporates the concepts of Six Sigma and Lean Six Sigma to elucidate the innovative techniques employed for minimizing waste and optimizing production processes. Results: The findings highlight the significance of operations management in pharmaceutical manufacturing, particularly in ensuring the rapid and high-quality production of parenteral preparations. The study underscores multinational corporations' successful implementation of operations management and alignment with Six Sigma and Lean Six Sigma principles. Conclusion: In conclusion, the research underscores the pivotal role of operations management in the pharmaceutical industry, offering novel solutions for total quality management and emphasizing the distinction between traditional and contemporary operations management.