Background: Diabetes mellitus is a disease of insulin deficiencyleads to micro and macro vascular disorder. Neuropathy is one of the major complication of chronic uncontrolled Diabetes affecting the Reaction time. Objectives: To study the correlation between the glycosylated HbA1C and Auditory, visual Reaction time in chronic Type II diabetes (40-60y) of on oral hypoglycemic drugs of> 10 y duration in two groups (n-100 in each group, both Males & females) and compared within the study groups and also with the age matched control group (100). Materials and Methods: HbA1C-Glycosylated HbA1C was measured by Particle enhanced immunoturbidimetric test method. Auditory and visual reaction time (ART, VRT) were measured by PC 1000 Reaction timer for control & study groups i.e. Group-I-Chronic Type II DM for > 10 y with HbA1c < 7.0, and Group II - chronic Type-IIDM for > 10 y with HbA1c > 7.0 ie impaired glycemic control. Exclusion Criteria-Subjects with Auditory and visual disturbances, alcoholism and smoking. Statistical Analysis - One-way ANOVA. Using SPSS 21 software. Result: Both the groups had prolonged ART and VRT than controls. Among the study group, G-II (DM with HbA1C > 7) had increased Auditory & Visual Reaction time than Group I which is statistically significant p-value < 0.05. Conclusion: Impairment of sensory motor function of peripheral nervous system is more in chronic diabetic with less glycemic control ie., HbA1C>7 who have shown increased Auditory and Visual Reaction time than chronic DM with HbA1C<7. Severity of Peripheral neuropathy in Type II Diabetics could be due to elevated HbA1C.