Background: Stroke causes long-term disability, affecting physical, cognitive, and psychological aspects. A nurse-led bundle care approach is proposed to provide comprehensive post-acute care, enhancing recovery and quality of life for stroke patients and their caregivers. Methods: The study conducted a thorough literature search in major databases, identifying relevant studies that met eligibility criteria. The PICO framework was used to guide the review, and the included studies were evaluated for bias risk and evidence quality. Results: The final analysis of 12 studies revealed that nurse-led bundle care interventions significantly reduced post-acute stroke complications, including functional decline (P < 0.05), cognitive impairment (P < 0.01), and psychosocial distress (P < 0.001), compared to standard care. Conclusion: The nurse-led bundle approach, which is coordinated and comprehensive, has shown positive outcomes in stroke patients transitioning from acute to post-acute settings, indicating potential benefits.