In the present investigation, the bioefficacy of an indigenous plant was investigated with special reference to its antioxidant potential. Antioxidant effects of Methanolic, Chloroform and Ethyl acetate extracts of the leaves of Premna corymbosa Rottl. (family Verbanaceae) were tested on the basis of DPPH (1, 1diphenyl-2-picryl-hydrazyl), phosphomolybdenium assay, super oxide radical scavenging activity and metal chelating activity. Results pertaining to the present investigation clearly indicate that the methanol extract of the P. corymbosa showed strong antioxidant activities than the other solvent extracts. This study has made it clear that Premna corymbosa is an effective anti oxidant. Such extracts could be more widely used in developing countries for prevention and treatment of cancer. These extracts may be considered as good sources for drug discovery.