Introduction: Saliva has been used as sample for point of care monitoring. In addition to its feasibility of use, the advantages of saliva when compared to other body fluids, the new technically advanced methods to detect the biomarkers of interest in saliva rendered the point of care testing (POCT) for wider applications.Significance of POCT: An accurate, quick and portable POCT is ideally required for hospital, laboratory and personal ap-plications. Together with point of care diagnostics, the scientifically validated numerous upcoming biomarkers will extend their applicability for real time health tracking and personalized precision medicine in different areas of health care systems. The utilization of salivary POC analytical procedures is perhaps in its emerging stage.Conclusion: This paper summarizes the overall perception regarding the salivary point of care testing and its applications.