Aim: The aim of the study was to evaluate the serum lipid profile among untreated oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSMF) patients. Materials and Methods: This study was done in three groups of patients -OSMF, OSCC, and control. There are twenty participants in each group. Calorimetric method using semi-autoanalyzer was used for analyzing the lipid levels (cholesterol, triglycerides [TGL], and high-density lipids [HDL]) after collecting 2 ml of fasting blood from these patients. Low-density lipid [LDL] values were obtained by calculator method. Results: There was a significant decrease in serum lipid levels of patients with OSMF and OSCC. Conclusion: The decrease in lipid levels in OSMF and OSCC patients is due to its utilization by the cells during the cancer process.