Antiinflammatory activity of 4,5-disubstituted-3-methyl-1,3a, 4,5-tetrahydropyrazolo [3,4-c] pyrazoles

Bhaskar, V. H. and Balakrishnan, B. R. and Sangameswaran, B. (2007) Antiinflammatory activity of 4,5-disubstituted-3-methyl-1,3a, 4,5-tetrahydropyrazolo [3,4-c] pyrazoles. INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 17.0 (2). pp. 131-134. ISSN 0971-1627

Full text not available from this repository.

Abstract

Ethyl acetoacetate (I) was stirred with hydrazine hydrate in ethanol to get 5-methyl-2,4-dihydro-3H-pyrazol-3-one (II). This was refluxed with different aryl aldehydes in gl acetic acid in presence of fused sodium acetate to get corresponding (4Z)-4-arylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-ones (IIIa-f). These III were treated with 2,4-dinitrophenylhydrazine to get a series of 4,5-disubtituted 3-methyl-1, 3a,4,5-tetrahydropyrazolo [3,4-c] pyrazoles. The structures of the compounds have been established based on their analytical and spectral data. All the compounds have been screened for their antiinflammatory activity. Compound IVb and IVd exhibited good antiinflammatory activity.

Item Type: Article
Depositing User: Unnamed user with email techsupport@mosys.org
Last Modified: 06 Feb 2026 06:51
URI: https://ir.vmrfdu.edu.in/id/eprint/6158

Actions (login required)

View Item
View Item