A facile synthesis of (2E) substituted-2-ethylidene-5,6-diphenylimidazo [2,1-b] [1,3] thiazol-3-(2H)-ones (4a-f) has been achieved by the condensation of 4,5-diphenylimidazolin-2-thiones (3) with chloroacetic acid and aldehydes in presence of acetic anhydride, anhyd sodium acetate and gl acetic acid. The 4,5-diphenylimidazolin-2-thione on the other hand have been prepared by fusion of benzoin (1) and thiourea (2). The synthesized compounds have been characterized by IR and H-1 NMR spectral and elemental data. The title compounds were evaluated for their antifungal activity and found to exhibit a variable degree of activity.