BACKGROUND Termination of pregnancy has been legalised in India in 1971, mainly to prevent the complications of illegal abortions. Surgical methods of termination in second trimester are not without maternal risks and complications. A search for safer and easier methods of termination of pregnancy prompted by numerous potential complications has resulted in various medical approaches. Hence, prostaglandins were thought to be the answer. Using vaginal misoprostol was cheaper and more effective compared to other methods. The aim of this study was to study the safety and efficacy of vaginal misoprostol in second trimester termination of pregnancy. MATERIALS AND METHODS This is a study involving 75 patients who attended the OBG OPD for second trimester termination between the period of 2007 and 2012 with the inclusion criteria of singleton pregnancy in both nulliparous and multiparous patients with gestational age between 14 and 24 weeks using 400 micrograms to 1200 micrograms of vaginal misoprostol. RESULTS The present study further documents the positive experience on the safety and efficacy of misoprostol (PG E1 analogue) in the vaginal route in inducing second trimester abortion. CONCLUSION Misoprostol is really a wonder drug with safety and efficacy in achieving the second trimester abortion by medical methods, costeffective and easy to administer with minimal side effects.