IntroductionDiabetes mellitus is a growing global health concern, with an estimated 643 million individuals projected to be affected by 2030. Sarcopenia, once considered a normal part of aging, is now known to be associated with chronic diseases, including type 2 diabetes mellitus (T2DM). Muscle mass typically declines by approximately 8% per decade after age 40, accelerating to 15-25% per decade after age 70.AimTo determine the prevalence of sarcopenia in patients with T2DM of more than 10 years' duration and evaluate its association with bone mineral density (BMD).MethodsAn observational study was conducted at a tertiary care hospital in Salem from January to October 2024. A total of 120 patients with T2DM for over 10 years were included. Data collected included demographics, medical history (fractures, comorbidities, use of insulin, bisphosphonates, or vitamin D supplements), and physical examination findings (weight, height, BMI, and blood pressure). Sarcopenia and BMD were assessed using dual-energy X-ray absorptiometry (DEXA).ResultsThe mean age of participants was 63.4 +/- 8.7 years. Most had diabetes for 10-15 years (56.7%), and 32.5% had 16-20 years. The mean BMI was 25.7 +/- 3.4 kg/m2. Sarcopenia was present in 30.0% of participants. Additionally, 48.3% had osteopenia and 28.3% had osteoporosis.ConclusionRoutine screening for sarcopenia and BMD in older adults with long-standing T2DM is essential for early intervention. Good glycemic control may help mitigate the risk of sarcopenia and related complications.