In the present study, Miglitol 25 mg controlled release matrices were prepared by direct compression and in vitro drug dissolution studies were performed to find out the drug release rate and patterns. Hydroxypropylmethylcellulose, Hydroxypropylcellulose and Hydroxyethylcellulose were used as rate controlling polymers. Hydroxypropylmethylcellulose was used as primary rate controlling polymer and effects of addition of Hydroxypropylcellulose and Hydroxyethylcellulose on in-vitro drug dissolution were studied. Tablets were formulated using total polymer content as 30, 35 and 40 percent with 20 percent standard polymer content of Hydroxypropyl methylcellulose in all batches and varying the concentration of Hydroxypropyl cellulose and Hydroxyethylcellulose in the range of 10, 15 and 20 percent. In-vitro drug release was carried out using USP Type II at 50 rpm in 900 ml of acidic dissolution medium (pH 1.2) for 2 hours, followed by 900 ml alkaline dissolution medium (pH 7.4) up to 12 hours. Several kinetic models were applied to the dissolution profiles to determine the drug release kinetics.