Background: Diabetic foot infections are a common cause of morbidity and mortality. This study was conducted in diabetic patients with foot ulcers to determine the bacterial profile and their anti-microbial pattern. Of the 68 patients, 44 were males and 24 were females. The presence of diabetic neuropathy was observed in 43(63.2%) patients. The swabs from 56 patients showed a positive culture and 12 patients did not grow any organisms. A total of 92 organisms were isolated from 56 patients with growth. 12(17.6%) patients had polymicrobial infections. S. aureus (26.1%) was the predominant pathogen which was isolated, followed by E. coli (18.4%). Methods: This study was conducted on clinical specimens which were taken from 68 patients with diabetic foot infections, over a 1 year period. The clinical specimens were processed by using the standard aerobic microbiological techniques. The antimicrobial susceptibility pattern was studied by the Kirby-Bauer disc diffusion method. Result: S. aureus was the most common isolate which was recovered from 26.1% of the cases. Other organisms which were isolated were E. coli (18.4%),, Klebsiella (9.7%), Proteus spp (6.5%), NFGNB(14.1%),, Pseudomonas aeruginosa (13%) and Enterococcus spp (4.3%). Conclusion: The anti-microbial susceptibility data from our study suggests that piperacillin/tazobactum or cefeperazone /sulbactum would be appropriate for antibiotic coverage.