In cancers, many signals were involved in self-renewal, differentiation and proliferation. Especially, Wnt signaling pathway plays crucial impact in stem cells and cancer development. Wnt genes were involved in stimulation of Wt signaling pathway in stem cells development. Despite, mutation and over expression of Wnt genes induced regulation of carcinogenesis. Out of 19 Wnt genes, each Wnt gene has crucial role in growth of stem cells and cancer stem cells. In cancer stem cells, aberrant expression of Wnt genes implicated variety of cancer. Clinical studies, Inhibition of Wnt signaling pathway one of expensive strategies of cancer therapy. Drugs were developed against cancer development based on inhibition of abnormality of Wnt signalling.