Fabrication of Silver Nanocomposite on Copper Metal- A Potential Strategy to Alleviate Pelvic Inflammatory Disease

Prabasheela, B. and Sakithya, V (2020) Fabrication of Silver Nanocomposite on Copper Metal- A Potential Strategy to Alleviate Pelvic Inflammatory Disease. INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 10.0 (5). L127-L137. ISSN 2250-0480

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Abstract

Nano silver particle (NSPs), is one of the most attractive nano materials, and has been widely used in a range of biomedical applications, including diagnosis, treatment, drug delivery, medical device coating, and for personal health care. Silver nanoparticles can be synthesized by various methods but citrate reduced and stabilized particles gain an advantage over other methods because of its morphology, stable nature, cost effective and easy scale-up nature. In the present study, the silver nanoparticle was synthesized by reducing silver salt with sodium citrate that showed the characteristic peak at 410 nm by means of UV-Visible spectroscopy. Antibacterial activity was performed against S.aureus and P.aeruginosa, and S.aureusand was found to be more susceptible. Characterized colloidal silver nanoparticles were used for the coating process. Coating on copper plate was achieved by Dip method, and characterized using SEM, EDAX and FTIR. Resulting EDAX and SEM images showed the morphology of the coated surface with their elemental composition. FTIR interferogram showed the characteristic functional groups at 1290.09 cm(-1) and 1483.68cm(-1) responsible for the reduction of silver salt into silver nanoparticles. Antimicrobial activity was performed for the coated metal against the Trichomonasvaginalis, a sexual transmitted pathogen that attribute to pelvic inflammatory disease (PID).The inhibition diameter is of about 31mm, thereby considering the fabricated nano composite to be effective against the disease causing microbial species. Invitro cytotoxicity studies in the Vero cell line show 81% viability with no significant morphological alterations. Hence, the fabricated nano composite could be a future benchmark for implant functionalization.

Item Type: Article
Uncontrolled Keywords: Silver nanoparticles, Trichomonas vaginalis, intrauterine device, copper, pelvic inflammatory disease
Subjects: Chemistry > Chemistry
Divisions: Medicine > Aarupadai Veedu Medical College and Hospital, Puducherry, India > Biotechnology
Depositing User: Unnamed user with email techsupport@mosys.org
Last Modified: 06 Feb 2026 06:49
URI: https://ir.vmrfdu.edu.in/id/eprint/5777

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