Chronic Renal Failure is a worldwide public health problem with an increasing incidence and prevalence, poor outcomes and high costs. The health teaching regarding hemodialysis and self care is important to improve the health and wellbeing for patients with chronic renal failure. The aim of the study was to evaluate the effectiveness of Self care compliances among patients undergoing hemodialysis at selected hospital. Research design used for the study was quasi experimental research design. 20 samples were selected by non probability purposive sampling technique. After self introduction and explanation, collected the demographic and clinical variables, assessed self care compliances with 5 point rating scale. After pretest interventions given regarding self care compliances. Posttest has been done after 4 weeks. The result revealed that the mean score during pretest in experimental group was 43.20 +/- 6.79 whereas in control group was 41.70 +/- 6.42 with the mean difference 1.5 and the calculated independent 't' test value found to be t = -44.886. It shows highly significant difference (P<0.05) between experimental and control group respectively. The mean score of posttest level of self-care compliances in experimental group was 155.00 +/- 4.78 whereas in control group was 44.400 +/- 6.397 with the mean difference 110.6 and the calculated independent 't' test value found to be t =-9.000. Statistically it shows highly significant difference (P<0.05) in level of self care compliances between experimental and control group among patients undergoing hemodialysis. The finding revealed that there is a significant improvement in self care compliances after intervention.