Introduction: This study aimed to compare and evaluate the knowledge and awareness of general practitioners, specialists, and consultants in dental and medical healthcare regarding the management strategies of temporomandibular disorders (TMD) and orofacial pain (OFP) encountered in three regions: Bahrain, the UAE, and India. Materials and methods: This cross-sectional study was conducted among general practitioners, specialists, and consultants in dental and medical healthcare from Bahrain, the UAE, and India. A self-administered online Google survey was circulated via email and WhatsApp media to collect the data. The survey was sent to 250 medical and 250 dental practitioners through Google Forms. The survey consisted of 19 questions divided into four sections, which included demographics (five questions), types of TMD (four questions), treatments given for TMD (eight questions), and the fourth section contained types of OFP and treatment preferences (two questions). The collected data were recorded and statistically analyzed. Results: Among the 296 respondents, 244 were dental professionals, and 52 were medical professionals. The respondents were from three countries, namely Bahrain (19.6%), UAE (28.7%), and India (51.7%). Of the 296, only 187 were familiar with TMD/OFP. In this target healthcare professional group, the dental professionals (28%) encountered symptomatic TMD patients more frequently than medical professionals (7%). General practitioners (30.4%) were the most represented group, followed by specialists (30.1%). Indian dentists reported seeing the highest number of OFP patients compared to those in Bahrain and the UAE.The dental practitioners often managed the cases with bite splints/occlusal guards (88.2%), followed by occlusion correction/braces (70.6%) and prescription medication (78.6%). Conclusion: A significant level of awareness regarding TMD and OFP among healthcare professionals, particularly dental practitioners, was noted across the geographies, with a major diversity in the management of TMD/OFP. Clinical significance: The study provides valuable insights into the frequency of TMD and OFP encountered in three diverse regions and the types of management done.The study enables the identification of the gaps in knowledge and management approaches.The findings can aid in focusing on targeted continuing education and interdisciplinary training, allowing a more patient safety approach with better quality of life. © (2025), (Jaypee Brothers Medical Publishers (P) Ltd). All rights reserved.