Background: The aim of this study was to assess and compare the efficacy of curcuminoid gel as an adjuvant to scaling and root planing (SRP) in chronic periodontitis patients. Materials and Methods: Thirty subjects participated in this randomized controlled study. The control sites received SRP alone, while the experimental sites received curcuminoid gel as a local drug delivery in addition to SRP. Clinical parameters such as the Gingival Index, Oral Hygiene Index-Simplified, probing pocket depth, and clinical attachment level were assessed at baseline and 3-month posttreatment. In both control and test sites, prostaglandin E2 (PGE2) levels in gingival crevicular fluid (GCF) were assessed at baseline and 45 days posttreatment. Results: Parametric tests of significance were used for statistical analysis. Results revealed a statistically significant difference between the groups in both clinical and biochemical parameters. Conclusion: In treating moderate chronic periodontitis, the adjunctive use of curcuminoid gel significantly improved clinical outcomes compared to SRP alone. Following the procedure, the PGE2 level in GCF was substantially lower in the test sites than in the control sites. Controlled release mechanisms lessen inflammation and prevent recolonization for an extended period. Given the limitations of the study, curcuminoid gel may be utilized in addition to nonsurgical periodontal treatment. © 2025 Indian Society of Periodontology.