The Treponemadenticola, an oral spirochete is implicated in causation of periodontal disease. The same is implicated in car-cinogenesis via a number of potential mechanisms. The oral microbial dysbiosis, promotion of tumorigenesis, aiding in cell migration, enhancement of tumor depth or contribution in invasion were cited before. The tumorsphere modifications and co-existing inflammatory mediator allured Macrophage (M2) alterations were additionally described as contributory to oral cancer biology. The isolation and associations of T denticola and impacted direct and indirect mechanisms in oral carcinogenesis is presented in this review. © 2021 Elsevier B.V., All rights reserved.