Due to considerable alterations in individual bone structure, the residual ridge is constantly under the stress of bone resorption. In certain circumstances, this can cause disproportionate bone deterioration, making restorative dental management difficult. This inimitable curative procedure in the oral cavity is affected by specific factors in the oral tissue. A variety of HIFs are expressed during the healing of oral wounds in comparison to skin wounds. The target of this review article was to look at a cistron tic connotation among SNP of the HIF-1 α gene that is understood to own great genetic diversity, and also the residual ridge reabsorption (RRR). Hence, this review concentrates on the association and genetic basis of HIF α gene in residual ridge resorption. © 2022 Elsevier B.V., All rights reserved.