Background: Bacteriophages are viruses that are used to destroy bacteria without harming host cells. As a result, it is thought that they can be used to treat bacterial infections alone or in conjunction with antibiotics. Pseudomonas aeruginosa, a multidrug-resistant bacterial pathogen, is one of the most prevalent infections in diabetic foot ulcers and has a high fatality rate. This bacterium produces a biofilm that causes recurring infections that are antibiotic-resistant and causes severe tissue damage with varying levels of severity. In this review, the role of bacteriophage therapy in diabetic foot ulcers, their advantages, limitation, and future perspectives will be discussed. The bacteriophage therapy to combat antibiotic-resistant bacteria is quite appealing, and some study data suggests that it could be a reasonable solution to overcome severe bacterial infections which cannot be treated by antibiotics. Some studies revealed that bacteriophage can be combined with antibiotics and used for effective treatment. However, phage therapy application in human treatment is scanty because the concurrent and underlying mechanism of this strategy is ambiguous among clinicians. Additionally, there are still problems with how to create formulas for standardized and therapeutic use in bacterial control. More study that is specifically devoted to resolving these problems is necessary before bacteriophages can be used in humans. Bacteriophage therapy will be a better choice for treating diabetic foot ulcers once everything has been cleaned up, and the incidence of amputation can be decreased by bacteriophage therapy. © 2024 Elsevier B.V., All rights reserved.