In the digital age of learning, new learning ecologies provide students with new web-based learning opportunities and resources. Medical education is reaching a new trend in teaching–learning methods by providing student-centered teaching. Flipped classroom is one among the teaching–learning methods. The contribution of the flipped classroom to education is discussed in relation to the changes in students’ and instructors’ roles. Subsequently, flipped classroom advantages and drawbacks are illustrated. For the current article literature was searched in databases PubMed and Scopus and only articles related to medical teaching were included. Studies on non-academic or informal settings without relevance to flipped classrooms were excluded. The study’s findings suggest that creating successful flipped classroom environments may be aided by carefully considering the cautions and suggestions given in the literature and also this article attempts to inform those who are thinking of using new technologies and approaches to deliver courses. © 2025 Elsevier B.V., All rights reserved.