A facile synthesis of (2E) substituted-2-ethylidene-5,6-diphenylimidazo [2,1-b] [1,3] thiazol-3-(2H)-ones (4a-f) has been achieved by the condensation of 4,5-diphenylimidazolin-2-thiones (3) with chloroacetic acid and aldehydes in presence of acetic anhydride, anhyd sodium acetate and gl acetic acid. The 4,5-diphenylimidazolin-2-thione on the other hand have been prepared by fusion of benzoin (1) and thiourea (2). The synthesized compounds have been characterized by IR and 1H NMR spectral and elemental data. The title compounds were evaluated for their antifungal activity and found to exhibit a variable degree of activity. © 2006 Elsevier B.V., All rights reserved.