The effect of ethyl acetate extract of Sarcostemma brevistigma was investigated in rat to evaluate the antiinflammatory activity. Carrageenin-induced rat paw edema model and cotton pellet granuloma methods were employed to test antiinflammatory activity. The ethyl acetate extract (650 mg/kg) produced the inhibition of carrageenin-induced rat paw edema and also found to be effective in cotton pellet granuloma studies. The result indicated that the ethyl acetate extract produced significant (P<0.001) antiinflammatory activity when compared to control. © 2010 Elsevier B.V., All rights reserved.