Jeyakumar, Rangasamy (16245446300) and Rajesh, Rangasamy (59574097800) and Rajaprabhu, D. (16246346300) and Ganesan, Balaraman (16244437900) and Buddhan, Sivaprakasam (17342142300) and Anandan, Rangasamy (57202699103) (2009) Hepatoprotective effect of Picrorrhiza kurroa on antioxidant defense system in antitubercular drugs- induced hepatotoxicity in rats. African Journal of Biotechnology.
Full text not available from this repository.Abstract
The hepatoprotective effect of the ethanol extract of Picrorrhiza kurroa rhizomes and roots (PK) on liver mitochondrial antioxidant defense system in isoniazid and rifampicin-induced hepatitis in rats was investigated. In liver mitochondria of antitubercular drugs administered rats, a significant elevation in the level of lipid peroxidation with concomitant decline in the level of reduced glutathione and in the activities of antioxidant enzymes was observed. Co-administration of PK (50 mg/kg/day for 45 days) significantly prevented these antitubercular drugs-induced alterations and maintained the rats at near normal status. © 2009 Academic Journals. © 2009 Elsevier B.V., All rights reserved.
| Item Type: | Article |
|---|---|
| Subjects: | Agricultural and Biological Sciences > Agronomy and Crop Science Biochemistry, Genetics and Molecular Biology > Biotechnology Biochemistry, Genetics and Molecular Biology > Genetics Biochemistry, Genetics and Molecular Biology > Molecular Biology Immunology and Microbiology > Applied Microbiology and Biotechnology |
| Depositing User: | Unnamed user with email techsupport@mosys.org |
| Date Deposited: | 24 Dec 2025 11:37 |
| Last Modified: | 24 Dec 2025 11:37 |
| URI: | https://ir.vmrfdu.edu.in/id/eprint/5202 |
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