Hepatoprotective activity of the Infusion of the dried leaves of Cassia alata (ICA) was studied against Paracetamol induced hepatic injury in albino rats. Pretreatment of the Infusion (ICA) reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase (SGPT), serum oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP). Histopathological observations also revealed that pretreatment with ICA protected the animals from paracetamol induced liver damage. The results indicate that the leaves of C.alata possess the Hepatoprotective activity. This property may be attributed to the flavonoids present in the leaves of C. alata. © 2010 Elsevier B.V., All rights reserved.