The study was conducted to evaluate the effectiveness of regulations on antibiotic utilization after oral route of administration. It was performed before and after imposing regulations on antibiotics administration. The uses of all antibiotics were regulated using drug formulary and restrictions in the prescribing pattern. All the hospitalized patients in the medical ward were subjected for evaluation. Significant changes in the total doses of antibiotics consumed in the oral routes were observed. This led to effective and rational use of antibiotics. © 2012 Elsevier B.V., All rights reserved.