Plants are reservoirs of potent and safe anti-oxidant molecules. The isolation and identification of such molecules may lead to the development of new drugs that can be used to control or prevent many diseases. Caesalpinia mimosoides Lamk (Caesalpiniaceae) is a climbing shrub found throughout India. In the present study the ethanolic extract of aerial parts of C.mimosoides was investigated for its in-vivo anti-oxidant activities by conducting assay of superoxide dismutase, catalase, glutathione, glutathione peroxidase, glutathione reductase. The analysis of the result showed that the plant possesses significant anti-oxidant activity. © 2015 Elsevier B.V., All rights reserved.