Virtual screening of phenylsulfonamido-3-morpholinopropan-2-yl dihydrogen phosphate derivatives as novel inhibitors of MurC–MurF ligases from Mycobacterium leprae

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Shanmugam, Anusuya and Anbazhagan, Venkattappan and Natarajan, Jeyakumar (2012) Virtual screening of phenylsulfonamido-3-morpholinopropan-2-yl dihydrogen phosphate derivatives as novel inhibitors of MurC–MurF ligases from Mycobacterium leprae. Medicinal Chemistry Research, 21 (12). pp. 4341-4351. ISSN 1054-2523

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Abstract

This study designed phenylsulfonamido-3-morpholinopropan-2-yl dihydrogen phosphate derivatives as multi-targeted inhibitors of MurC, MurD, MurE, and MurF ligases in Mycobacterium leprae for anti-leprosy therapy. Virtual screening identified 1-(3-acetyl phenyl sulfonamide)-3-morpholino propan-2-yl dihydrogen phosphate as a novel multiple inhibitor. © 2017 Elsevier B.V., All rights reserved.

Item Type: Article
Subjects: Chemistry > Organic Chemistry
Pharmacology, Toxicology and Pharmaceutics > Pharmacology
Pharmacology, Toxicology and Pharmaceutics > Pharmaceutics
Pharmacology, Toxicology and Pharmaceutics > Toxicology
Divisions: Medicine > Aarupadai Veedu Medical College and Hospital, Puducherry, India > Microbiology
Depositing User: Unnamed user with email techsupport@mosys.org
Last Modified: 10 Dec 2025 06:57
URI: https://ir.vmrfdu.edu.in/id/eprint/4274

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