Vadhanan, Prasanna and Tripaty, DebendraKumar and Adinarayanan, S (2015) Physiological and pharmacologic aspects of peripheral nerve blocks. Journal of Anaesthesiology Clinical Pharmacology, 31 (3). p. 384. ISSN 0970-9185
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Official URL: https://doi.org/10.4103/0970-9185.161679
Open Access PDF Link: https://doi.org/10.4103/0970-9185.161679
Abstract
A successful peripheral nerve block requires knowledge of physiology and pharmacology of local anesthetics (LAs). This article explains pharmacodynamics of LAs, differential blockade, tachyphylaxis, C-fiber resistance, tonic/phasic blockade, and volume/concentration effects. New neurotoxin-based anesthetics show potential.
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