Predictive medicinal metabolites fromMomordica dioicaagainst comorbidity related proteins of SARS-CoV-2 infections

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Sakshi, Chavan and Harikrishnan, A. and Jayaraman, Selvakumar and Choudhury, Ahana Roy and Veena, V. (2022) Predictive medicinal metabolites fromMomordica dioicaagainst comorbidity related proteins of SARS-CoV-2 infections. Journal of Biomolecular Structure and Dynamics, 40 (11). pp. 5175-5188. ISSN 0739-1102

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Abstract

Momordica dioica bioactive flavonoids and triterpenoids were studied for antiviral, antidiabetic, and immunomodulatory activity against SARS-CoV-2. Molecular docking and in silico ADME analysis showed hederagenin and oleanolic acid had superior binding to viral proteins (Mpro, RdRp, spike, ACE2, DPP4) compared to catechin, quercetin, and standard drugs. Quercetin demonstrated good safety and gastrointestinal permeability. The study indicates M. dioica compounds have therapeutic potential against SARS-CoV-2 infections, particularly under comorbid conditions. © 2022 Elsevier B.V., All rights reserved.

Item Type: Article
Subjects: Biochemistry, Genetics and Molecular Biology > Molecular Biology
Biochemistry, Genetics and Molecular Biology > Structural Biology
Divisions: Engineering and Technology > Aarupadai Veedu Institute of Technology, Chennai, India > Mechanical Engineering
Depositing User: Unnamed user with email techsupport@mosys.org
Last Modified: 02 Dec 2025 09:40
URI: https://ir.vmrfdu.edu.in/id/eprint/3045

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