A facile novel synthesis of spirooxindole-3,4′-pyran derivatives was achieved using FeCl₃ as a catalyst in a one-pot three-component reaction. This cascade reaction delivered a maximum yield of approximately 98%. A total of 28 derivatives were synthesized using a multicomponent reaction (MCR) via a single-step process. The mechanism proceeds through fast Knoevenagel condensation, Michael addition, and catalyst recovery. The scope and limitations of the reaction were explored using various isatin derivatives and active methylene compounds. Structural confirmation was performed using FT-IR, ¹³C NMR, ¹H NMR, single-crystal XRD, and mass spectrometry, all indicating good product yields. © 2025 Elsevier B.V., All rights reserved.