Production of β‐glucoribofructan from gut‐associated Bacillus spizizenii VSMKU0112 against inflammatory bowel disease

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Ravindran, Deepthi Ramya and Kannan, Suganya and Thangaswamy, Selvankumar and Veeranan, Vimala Devi and Vellasamy, Shanmugaiah (2025) Production of β‐glucoribofructan from gut‐associated Bacillus spizizenii VSMKU0112 against inflammatory bowel disease. Polymer International. ISSN 0959-8103

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Abstract

This study characterizes Bacillus spizizenii VSMKU0112-derived extracellular polymeric matrix (EPM), named β-glucoribofructan (β-GRF), a heteropolysaccharide of β-linked fructose, glucose, and ribose. β-GRF showed antioxidant, antidiabetic, anti-inflammatory, and antilipidemic activities. Simulated gastrointestinal digestion and gut microbiota studies revealed enhanced short-chain fatty acid production and improved microbial colonization, suggesting potential therapeutic impact in metabolic-regulated inflammatory bowel disease.

Item Type: Article
Subjects: Chemistry > Organic Chemistry
Material Science > Materials Chemistry
Material Science > Polymers and Plastics
Divisions: Medicine > Vinayaka Mission's Medical College, Kottucherry > Central Research Laboratory for Biomedical Research
Depositing User: Unnamed user with email techsupport@mosys.org
Date Deposited: 25 Nov 2025 08:48
Last Modified: 25 Nov 2025 08:48
URI: https://ir.vmrfdu.edu.in/id/eprint/1001

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